Gd−Hydroxypyridinone (HOPO)-Based High-Relaxivity Magnetic Resonance Imaging (MRI) Contrast Agents
نویسندگان
چکیده
منابع مشابه
P22 viral capsids as nanocomposite high-relaxivity MRI contrast agents.
Attachment of multiple chelated Gd(3+) ions to the interior of bacteriophage P22 viral capsids affords nanoscale MRI contrast agents with extremely high relaxivity values. Highly fenestrated "wiffleball" morphology is unique to P22 and assures water exchange between the environment and interior cavity of the capsid. The cavity of P22 "wiffleball" was functionalized with a branched oligomer comp...
متن کاملmagnetic resonance imaging contrast agents: a review of literature
magnetic resonance imaging (mri) contrast agents most commonly agents used in diagnosing different diseases. several agents have been ever introduced with different peculiar characteristics. they vary in potency, adverse reaction and other specification, so it is important to select the proper agent in different situations. we conducted a systematic literature search in medline/pubmed, web of s...
متن کاملmagnetic resonance imaging (mri)
basic physical principles of nuclear magnetic resonance imaging (n.m.r.i), a nonionizing medical imaging technique, are described. principles of nmri with other conventional imaging methods, ie, isotope scanning, ultrasonography and radiography have been compared. t1 and t2 and spin density (s.d.) factors and different image construction techniques based on their different combinations is discu...
متن کاملHigh-relaxivity MRI contrast agents: where coordination chemistry meets medical imaging.
The desire to improve and expand the scope of clinical magnetic resonance imaging (MRI) has prompted the search for contrast agents of higher efficiency. The development of better agents requires consideration of the fundamental coordination chemistry of the gadolinium(III) ion and the parameters that affect its efficacy as a proton relaxation agent. In optimizing each parameter, other practica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2009
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar800250h